America the new law designed simple synthesis of amino acids

14 researchers announced that they design a " non-natural chiral amino acids" simple synthesis method , is expected to promote the development of the chemical industry , especially the pharmaceutical industry .
Amino acids are a class of organic compounds containing amino and carboxyl known , is the basic unit of biological function of the protein macromolecules . Chiral non-natural amino acid molecule " enantiomers ", which has an important role in the drug development , chemical synthesis , catalysis and other industrial fields . Research team leader , Professor Yu Jinquan Scripps Institute of Xinhua News Agency , told reporters that the natural amino acid cheap and easy to get , but a narrow range , requiring the synthesis of chiral non-natural amino acids .Sellotape


I of money is also Distinguished Professor of Shanghai Institute of Organic Chemistry . He said that according to conventional synthetic methods for preparing each of the different non-natural amino acids have chiral starting materials using different synthesis , and their idea is to use the cheapest alanine as a common starting material for the synthesis of a one thousand hands on thousands of non-natural amino acids . To this end they solved one of the biggest challenges is to inert alanine methyl carbon-hydrogen bonds on the break under mild conditions and based on the need to install a new chemical functional groups , each fitted with a different functional groups can get different amino acids .Washi tape


There alanine methyl 3 carbon-hydrogen bonds , interrupting the first key and the second key will get different amino acids , but tend to occur consecutively and get the product mix and lose value. They successfully designed two different catalyst activity can be selectively interrupted by the first key and the second key so as to control the structure of amino acid synthesis .Masking tape


It is reported that they developed an unnatural amino acid having a chiral good pharmacological activity , potential applications include the manufacture of anti-cancer drugs, antibiotics, drugs for Parkinson 's disease and diseases . The research results have been published in the new issue of the journal "Science ."Wholesale masking tape